A teenager who lost her mother, aunt and uncle to a genetic condition has become the first person in Europe to receive a "life-changing" drug after it was approved for use on the NHS.Mary Catchpole, 19, suffers from activated PI3-Kinase delta syndrome (APDS), a rare inherited disorder that leaves people with a significantly weakened immune system.Patients with APDS are vulnerable to repeated infections and face a lifetime of antibiotics and invasive procedures to try and keep them well.Miss Catc

A teenager who lost her mother, aunt and uncle to a genetic condition has become the first person in Europe to receive a "life-changing" drug after it was approved for use on the NHS.Mary Catchpole, 19, suffers from activated PI3-Kinase delta syndrome (APDS), a rare inherited disorder that leaves people with a significantly weakened immune system.Patients with APDS are vulnerable to repeated infections and face a lifetime of antibiotics and invasive procedures to try and keep them well.Miss Catchpole's mother's side of the family has been badly affected by APDS - her mother Sarah died aged 43 in 2018, while her aunt Helen died aged 12, her uncle Edward when he was 39 and her grandmother Mary when she was 48.